1 2 Lysine - Enriched Cecropin - Mellitin Antimicrobial Peptides with 3 Enhanced Selectivity
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چکیده
1 Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA1-7 M2-9 (designated 2 CM15), designed with optimized amphipathicity retained antimicrobial activity similar to 3 wild type CM15 and had substantially reduced hemolytic activity and cytotoxicity 4 towards cultured macrophages, resulting in enhanced selectivity. These lysine-enriched 5 analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics. 6 7
منابع مشابه
1 2 Lysine - Enriched Cecropin - Mellitin Antimicrobial Peptides with 3 Enhanced Selectivity 4 5 6
1 Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA1-7 M2-9 (designated 2 CM15), designed with optimized amphipathicity retained antimicrobial activity similar to 3 wild type CM15 and had substantially reduced hemolytic activity and cytotoxicity 4 towards cultured macrophages, resulting in enhanced selectivity. These lysine-enriched 5 analogs provide templates for improved CM1...
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Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates fo...
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